A 16-year old girl with newly diagnosed asthma was started on a drug treatment. Three weeks later she presents with repeated abnormal movements shown below. The most likely culprit for her pathology is?
E. Cromolyn sodium
F. Marijuana use
Adenosine A2A receptor antagonists are a class of drugs that blocks adenosine at the adenosine A2A receptor. Notable adenosine A2A receptor antagonists include caffeine, theophylline and istradefylline.
This girl is presenting with classic orobuccal-lingual dyskinesias. These symptoms have been known to occur in the younger age population, and there is an association with asthma and theophylline.
Sporadic reports of theophylline causes tardive dyskinesias in young patients are well known
When theophylline is discontinued, recovery usually occurs in a few weeks.