A 46-year-old woman with active ankylosing spondylitis comes to the office for a follow-up examination. The use
of various conventional nonsteroidal anti-inflammatory drugs has been ineffective. Sulfasalazine treatment also has
not resulted in improvement. The most appropriate next step in treatment is administration of a drug that inhibits
which of the following?
(A) CD20
(B) Cyclooxygenase-2
© Cytotoxic T-lymphocyte antigen 4
(D) Epidermal growth factor
(E) Interleukin-1 (IL-1)
(F) Tumor necrosis factor α