A 53 year old woman has anorexia and increasing breathlessness

A 53 year old woman has anorexia and increasing breathlessness. She has stage 4 adenocarcinoma of the lung and now requires full support with her activities of daily living. She takes diazepam, cyclizine and zopiclone.

Investigations:

  • Sodium 122 mmol/L (135-146)
  • Potassium 3.2 mmol/L (3.5-5.3)
  • Urea 6.2 mmol/L (2.5-7.8)
  • Creatinine 58 mmol/L (45-95)

Which is the most appropriate management of her electrolyte disturbance?

  1. 1.8% sodium chloride by intravenous infusion
  2. DDAVP nasally
  3. Demeclocycline orally
  4. Fluid restriction
  5. No treatment indicated

E. No treatment indicated

Explanation:

Although she likely has SIADH, she is asymptomatic from this and so no palliative treatment of this is necessary.