A 60-year-old man who is being treated for multiple myeloma develops osteonecrosis of his maxilla


#1

A 60-year-old man who is being treated for multiple myeloma develops osteonecrosis of his maxilla. His presentation is significant for a molar tooth extraction site that has healed poorly four months after surgery. Localized swelling, exposed bone, erythema, and a purulent discharge are noted on intraoral examination. Which of the following drug classes is most likely associated with this lesion?

  • (A) Angiotensin converting enzyme inhibitors
  • (B) Bisphosphonates
  • © Cephalosporins
  • (D) Osmotic diuretics
  • (E) Vinca alkaloids

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A 35-year-old woman comes to the emergency department after returning home from a trip to Mexico with a one-week history of intractable vomiting. Laboratory tests show a serum bicarbonate level of 50.9 mmol/L, pH of 7.61, serum sodium of 125 mEq/L, potassium of 1.8 mEq/L, and chloride of 55 mEq/L. She is treated aggressively with fluid, electrolytes, and a diuretic. Which of the following is the most appropriate diuretic to treat this patient?

  • (A) Acetazolamide
  • (B) Ethacrynic acid
  • © Furosemide
  • (D) Hydrochlorothiazide
  • (E) Mannitol

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