A 70-year-old woman is prescribed bumetanide for congestive cardiac failure

A 70-year-old woman is prescribed bumetanide for congestive cardiac failure. Where is the site of action of bumetanide?

Descending loop of Henle
Macula densa
Ascending loop of Henle
Distal collecting duct
Proximal collecting duct

An 84-year-old female has become progressively more short of breath over the past 2 months. She is finding it difficult to breathe when lying down and so has been sleeping upright in her chair for the past two weeks. She also has a cough productive of frothy sputum and swollen legs. What is the most likely description of her pulse?

Pulsus alternans
Collapsing
Jerky
Slow rising
Pulsus bisferiens