A patient being treated with astemizole because

Ketoconazole should not be given to a patient being treated with astemizole because :

    1. Ketoconazole induces the metabolism of astemizole
    1. Dangerous ventricular arrhythmias can occur
    1. Astemizole inhibits the metabolism of ketoconazole
    1. Astemizole antagonizes the antifungal action of ketoconazole

0 voters

EXP:

Ketoconazole, erythromycin and clarithromycin are potent inhibitors of microsomal enzymes. Astemizole, terfenadine and cisapride are the drugs that can block cardiac K+ channels at high concentration. If administered along with microso-mal enzyme inhibitors, these drugs can result in torsades de pointes, a serious polymorphic ventricular tachycardia.