All of the following are true regarding oxygenases except
-
- Incorporate 2 atoms of oxygen
-
- Incorporate 1 atom of oxygen
-
- Required for hydroxylation of steroids
-
- Required for carboxylation of drugs
0 voters
exp:
- Mono-oxygenases incorporate one atom and dioxygenases incorporate two atoms of 0, into the substrate.
- Mitochondrial cytochrome P450 is found in steroidogenic - adrenal cortex, testis, ovary and placenta and is concerned with hydroxylation at C22 and C20 in side chain cleavage and at 11B and 18 positions during synthesis of steroid hormones from cholesterol. It catalyzes 1 a and 25 hydroxylation in Vit. D metabolism (in kidney) and 7 a hydroxylase and 27 hydroxylase in bile acid synthesis (in liver).