H1 antihistaminics afford benefit in a number of conditions. All of the following conditions are benefited by antagonism of histamine EXCEPT :
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- Dermographism
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- Insect bite
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- Common cold
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- Seasonal hay fever
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exp:
In this condition, excessive secretions (like rhinorrhoea) are due to cholinergic overactivity. First generation antihistamin-ics possess anticholinergic property and therefore are effective for common cold. On the other hand, second generation agents (lacking anticholinergic actions) are ineffective.