All of the following conditions are benefited by antagonism of histamine EXCEPT :

H1 antihistaminics afford benefit in a number of conditions. All of the following conditions are benefited by antagonism of histamine EXCEPT :

    1. Dermographism
    1. Insect bite
    1. Common cold
    1. Seasonal hay fever

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exp:

In this condition, excessive secretions (like rhinorrhoea) are due to cholinergic overactivity. First generation antihistamin-ics possess anticholinergic property and therefore are effective for common cold. On the other hand, second generation agents (lacking anticholinergic actions) are ineffective.