An A question has five answers, of which only one is correct.
Example:
Which anti-emetic schedule is the most appropriate for a patient receiving 70 mg/m2 cisplatin in combination with gemcitabine 1250 mg/m2 at day 1?
A. Metoclopramide in combination with dexamethasone at day 1
B. 5-HT3 receptor antagonist (e.g. ondansetron, granisetron) and dexamethasone at day 1
C. 5-HT3 receptor antagonist in combination with lorazepam at day 1
D. 5-HT3 receptor antagonist, aprepitant or fosaprepitant at day 1
E. 5-HT3 receptor antagonist, aprepitant or fosaprepitant, dexamethasone at day 1
Explanation:
The correct answer is E.
This chemotherapy schedule is classified as a highly emetic schedule and the standard of care in this situation is
a combination of 5-HT3 receptor antagonists, aprepitant or fosaprepitant and dexamethasone. All other schedules mentioned are less effective.