Antagonism of which neurotransmitter is most likely to improve her symptoms?


#1

A 78-year-old woman presented with a 9-month history of worsening urinary frequency and urge incontinence.
Examination was normal.
Investigations:
post-void bladder scan 10-mL residual volume
Antagonism of which neurotransmitter is most likely to improve her symptoms?

A: acetylcholine
B: adrenaline
C: dopamine
D: noradrenaline
E: serotonin

Correct answer: A Explanation Contraction of the bladder detrusor muscle is stimulated by acetylcholine. Anticholinergic agents inhibit the binding of acetylcholine to the cholinergic receptor, thereby suppressing involuntary bladder contraction of any aetiology.