Atypical ANCA (A-ANCA):


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Atypical ANCA (A-ANCA):


• Atypical pattern (also known as A-ANCA) is rare and combines both cytoplasmic and perinuclear or nuclear staining, with multiple antigen specificities.

• A-ANCA can occur in association with:

Autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, SLE, inflammatory bowel disease , rheumatoid arthritis, and drug exposure, most often in the absence of vasculitis.