Autoimmune disorders and Antibodies

:white_check_mark: Most sensitive antibody – ANA ( Anti-Nuclear Antibody)

:white_check_mark:Most specific antibody – anti Sm (smith) antibody

:white_check_mark: Most sensitive and specific both – anti dsDNA antibody.

:white_check_mark: Drug induced Lupus- anti-histone antibodies.

:white_check_mark: Most specific antibody in “Neonatal lupus with congenital Heart block” is Anti Ro (SS-A)

:white_check_mark:Antibody in SLE predisposes to photo toxicity – anti-RO (=SS-A) antibody.

:white_check_mark: “Shrinking lung syndrome” is characteristically associated with anti-RO (=SS-A) antibody.

:white_check_mark:Reynaud’s phenomenon in SLE is associated with antiU1 ribonucleoprotein (anti-U1 RNP) antibody.

:white_check_mark:Neuropsychiatric features are associated with Antiribosomal-P antibody.