Autoimmune hepatitis🌸
Most common autoimmune disease of liver in adults.
Chronic progressive liver disease
CD-8 T-cell mediated inflammation
Common in females
Etiology— viruses; drugs; autoimmune disorders (e.g.rheumatoid arthritis; sjogren syndrome or ulcerative colitis)
Classically females with elevated serum IgG levels but no serum makers of viral hepatitis.
Classification (on the basis of antibodies):
1)TYPE-1 AIH:-
Associated with HLA-DR3 haplotype.
Auto -Antibodies are:
a)ANA ( AntiNuclear—most common)
b) SMA (Smooth Muscle Actin —most specific )
c) SLA/LPA ( Soluble liver Antigen/ Liver Pancreas Antigen)
- TYPE-2 AIH :-
Auto antibodies are formed against:
a)LKM-1 (Liver-Kidney-Microsome)
b) LC-1 (Liver-Cytosol -1 antigen)
Auto antibodies are formed against:HISTOLOGY:-
Clusters of periportal plasma cells is characteristic.
Entire histologic spectrum of hepatitis is seen.
Immunosuppression is mainstay of therapy.
Transplantation for end stage disease with recurrence
Risk: - liver cell failure and cirrhosis.