CDC case definition for multisystem inflammatory syndrome in children (MIS-C).
(1)
An individual aged < 21 years with:
(2)
Clinical criteria:
A minimum 24-h history of subjective or objective fever ≥ 38.0 °C AND
Severe illness necessitating hospitalization AND
Two or more organ systems affected (i.e., cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, neurological)
(3)
Laboratory evidence of inflammation
One or more of the following: an elevated CRP, ESR, fibrinogen, procalcitonin, D-dimer, ferritin, LDH, or IL-6; elevated neutrophils or reduced lymphocytes; low albumin
(4)
Laboratory or epidemiologic evidence of SARS-CoV-2 infection
Positive SARS-CoV-2 testing by RT-PCR, serology, or antigen OR
COVID-19 exposure within 4 weeks prior to onset of symptoms
(5)
No alternative diagnosis
Abbreviations: CDC, Centers for Disease Control; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; RT-PCR, reverse transcriptase polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.