CDC case definition for multisystem inflammatory syndrome in children (MIS-C)

CDC case definition for multisystem inflammatory syndrome in children (MIS-C).

(1)

An individual aged < 21 years with:

(2)

Clinical criteria:

A minimum 24-h history of subjective or objective fever ≥ 38.0 °C AND

Severe illness necessitating hospitalization AND

Two or more organ systems affected (i.e., cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, neurological)

(3)

Laboratory evidence of inflammation

One or more of the following: an elevated CRP, ESR, fibrinogen, procalcitonin, D-dimer, ferritin, LDH, or IL-6; elevated neutrophils or reduced lymphocytes; low albumin

(4)

Laboratory or epidemiologic evidence of SARS-CoV-2 infection

Positive SARS-CoV-2 testing by RT-PCR, serology, or antigen OR

COVID-19 exposure within 4 weeks prior to onset of symptoms

(5)

No alternative diagnosis

Abbreviations: CDC, Centers for Disease Control; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; RT-PCR, reverse transcriptase polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.