Charcot leyden crystal
Asthma
:-atopic
:-nonatopic
:-drugs induced
:-occupational
:-Hypersensitivity 1 type reaction
:-genetic /atopic
:-5q chromosome increase IL 4 5 9 13 and IL⁴ receptors
:- b2 adrenergic gene
:- MHC Class ii : increased igE antibody
:- IL1 and 33 grop incrrase cytokines of th2 cells
:-thymic stromal lymphopoietin increase allergic response
:-ADAM 33 GENE :- fibrosis and increase smooth muscle hyperplasia
:-YKL 40 gene :- increase allergic response
Histo
:- remodeling
:-hyperplasia of smc
:-eosinophil infiltration
:-fibrosis
Sputum
:-charcot leyden crystal ( galectin 10)
:-curschmann body (mucoid)
:-creola body