Classically activated macrophages (=m1)

NEET PG Pathology
#1

MACROPHAGES:-

A) CLASSICALLY ACTIVATED MACROPHAGES (=M1)

• Involved in inflammation e.g microbicidal actions ; phagocytosis; killing microorganisms
Examples are —IL-1;2;6;8;TNF;IFN etc.

B ) ALTERNATIVELY ACTIVATED MACROPHEGES (=M2)

• Has - ANTI-INFLAMMATORY cytokines :

  1. IL-4;
  2. IL-10;
  3. IL-13
  4. TGF( transforming growth factor)-BETA
    Function— wound repair and fibrosis