Compounds found in green tea and red wine may block formation of toxic metabolites - epigallocatechin gallate, tannic acid.
Discovery may pave the way for therapies to treat inborn congenital metabolic disorders.
A new study suggests there is hope of treating certain inborn congenital metabolic diseases – a hope found in green tea and in red wine.
Most people with inherited metabolic disorders are born with a defective gene that results in a critical enzyme deficiency.
In the absence of a cure, many patients with inborn congenital metabolic disorders must adhere to a strict and demanding diet their entire lives.
*This new research finds that certain compounds found naturally in green tea and red wine may block the formation of toxic metabolites.
- The researchers considered two compounds: (1) epigallocatechin gallate, known as EGCG, found naturally in green tea, which has attracted attention within the medical community for its potential health benefits; and (2) tannic acid, found in red wine, which is known to prevent the formation of toxic amyloid structures that cause neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease.
Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Aviad Levin, Lihi Adler-Abramovich, Lela Vuković, Petr Král, Ehud Gazit. Differential inhibition of metabolite amyloid formation by generic fibrillation-modifying polyphenols. Communications Chemistry, 2018; 1 (1) DOI: 10.1038/s42004-018-0025-z