Decreased glycolytic activity imapairs oxygen transport by hemoglobin due to


#1

Decreased glycolytic activity imapairs oxygen transport by hemoglobin due to

    1. Reduced energy production
    1. Decreased production of 2,3 - bisphosphoglycerate
    1. Reduced synthesis of hemoglobin
    1. Low levels of oxygen

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Decreased production of 2,3-bisphosphoglycerate

  • 2, 3 DPG is produced by an alternative pathway in glycolysis.
  • If the glycolytic activity is decreased, the levels of 2,3 - DPG in RBCs will decrease.
  • Decreased level of 2,3 - DPG causes :-
  1. Shifts the oxygen - hemoglobin curve to the left
  2. Increases the oxygen affinity of hemoglobin.