Distal renal tubular acidosis is a disease that occurs when the kidneys do not properly remove acids from the blood into the urine

Distal renal tubular acidosis is a disease that occurs when the kidneys do not properly remove acids from the blood into the urine. As a result, too much acid remains in the blood (called acidosis).
#MAIN_CAUSES :
Type I RTA is caused by a variety of conditions, including:
*Amyloidosis, a buildup of abnormal protein, called amyloid, in the tissues and organs
*Fabry disease, an abnormal buildup in the body of a certain type of fatty substance
High level of calcium in the blood
*Sickle cell disease, red blood cells that are normally shaped like a disk take on a sickle or crescent shape
*Sjögren syndrome, an autoimmune disorder in which the glands that produce tears and saliva are destroyed
*Systemic lupus erythematosus, an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue
*Wilson disease, an inherited disorder in which there is too much copper in the body’s tissues
*Use of certain medicines, such as amphotericin B, lithium, and analgesics
#Clinical_features :
*Confusion or decreased alertness
Fatigue
*Impaired growth in children
*Increased breathing rate
*Kidney stones
Nephrocalcinosis (too much calcium deposited in the kidneys)
*Osteomalacia (softening of the bones)
*Muscle weakness
#Other symptoms may include:
*Bone pain
*Decreased urine output
*Increased heart rate or irregular heartbeat
*Muscle cramps
*Pain in the back, flank, or abdomen
*Skeletal abnormalities
#TREATMENT :
*The underlying cause of distal renal tubular acidosis should be corrected if it can be identified.
*Medicines that may be prescribed include potassium citrate and sodium bicarbonate. These are alkaline medicines that help correct the acidic condition of the body. Sodium bicarbonate may correct the loss of potassium and calcium.