Electron microscopy of Membranous Glomerulonephritis…“SPIKE and DOME” appearence…
☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆
● Electron-dense deposits (arrow-----Immune complex forming “DOME”) along the epithelial side of the basement membrane (B) forming SPIKE.
● Note the effacement of foot processes overlying deposits.
CL- Capillary Lumen;
End- Endothelium;
Ep- Epithelium;
US- Urinary Space…