Electron microscopy of Membranous Glomerulonephritis

Electron microscopy of Membranous Glomerulonephritis…“SPIKE and DOME” appearence…

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● Electron-dense deposits (arrow-----Immune complex forming “DOME”) along the epithelial side of the basement membrane (B) forming SPIKE.

● Note the effacement of foot processes overlying deposits.

CL- Capillary Lumen;
End- Endothelium;
Ep- Epithelium;
US- Urinary Space…