Genetic tumor markers and disease
• Oncogenes:
– N-ras: leukemia
– K-ras: colon/ gastric
– C-erB-2: Breast/gastric
– N-myc: Breast/Neuro
– c-abl/bcr: CML
– bcl-2: leukemia/lymp
– HER-2/INT2/ATM/
H-ras: Breast
– MCC: colon
• Tumor Suppressors:
– p53: Breast/colon/lung
– RB1: Retinoblastoma
– WT1& 2: Renal
– BRCA1& 2: Breast/
pancreatic/Ovarian
– BRCA1:prostate/stom.
– APC: Colorectal
– MTS1: Melanoma
– DCC: colon/gastric