Harrison's 19th E update on PD Treatment

Harrison’s 19th E update on PD
Treatment

  1. Drug of choice for PD - Levodopa
  2. Drug of choice in young onset PD - Pramipexole
  3. Drug of choice to reduce motor fluctuation of levodopa - Pramipexole
  4. Drug of choice for ON-OFF phenomena - Rasageline
  5. Carbidopa : Levodopa ratio = 1:4 or 1:10
  6. COMT inhibitor like Entecapone combined with Levodopa - To increase Levodopa bioavailability and duration of action.
  7. Only disease modifying drug class or neuroprotective - MAO inhibitor.

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