HBV serology , continued. …
HBsAb if positive alone , indicates vaccination , and the tire should be checked and if inadequate , booster dose is required .
HBcAb IgM indicates recent infection or flare of chronic infection .
HBeAg (envelope ) is a marker of infectivity and if positive , indicates high HBV DNA levels and highly infectious patient .
HBeAb is a marker of seroconversion and indicates lower infectivity .
So…
HBsAg +HBcAb IgM positive = recent infection .
HBsAg +HBcAb positive = chronic infection
HBsAg + HBcAb +HBeAg positive = chronic highly infectious
HBsAg + HBcAb + HBeAb positive = chronic carrier (less infectivity ).
HBsAb only positive = prior vaccination ( check titre for adequate immunity )
HBsAb + HBcAb positive = prior infection , cleared it .
Note …In some mutant forms HBsAg and HBsAb can coexist and the effect of this on the course of the disease is still unknown …(forget it for now )