Heterophile specificity/ Heterophile antigens
Antigens of different species cross react with each other.
Weil-Felix : Proteus OX2, OX19, OXK with Rickettsia
Streptococcus MG agglutination test: Streptococcus MG with Mycoplasma
Cold Agglutination test: Mycoplasma with human O+ve RBCs (@ 4 °C)
VDRL, RPR for Syphilis: Cardiolipin antigen (beef heart) with Treponemal antibody
Paul-Bunnel : EBV with Sheep RBC
Autoimmune diseases: eg.,Glomerulonephritis - Streptococcal antigens with human tissue