Liddle’s syndrome – Gain of function in collecting duct Na channel (ENaC) manifests as hypertension, hypokalemic alkalosis & normal aldosterone levels
Bartter syndrome- defect in the thick ascending limb of the loop of Henle, which results in hypokalemia, alkalosis, and normal to low blood pressure
Gitelman syndrome- NaCl cotransporter defect leading to hypokalemia, hypophosphatemia , hypocalciuria, and akalosis .
High urine chloride metabolic alkalemia with hypertension includes Conn’s Syndrome, Cushing disease, Liddle’s syndrome
High urine chloride metabolic alkalemia without hypertension include Excess IV bicarbonate administration, Gitelman syndrome, Bartter’s syndrome