Hormone from fat boosts metabolism in both exercise and cold
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Better understanding of signals to burn energy may eventually lead to treatments for obesity.
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Researchers have uncovered a new kind of clue to this variable response – a hormone whose levels in the bloodstream rise sharply in exercise as well as in cold.
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Experiments in both humans and mice have shown that levels of one lipokine, with the unwieldy name of 12,13-diHOME, climb significantly in exercise, unlike the levels of other lipokines analyzed.
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The investigation explored the release of lipokines from brown fat, which can burn energy in people or other mammals exposed to cold.
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In both humans and mice, the researchers demonstrated that the 12,13-diHome molecule was released from brown fat during cold exposure and offered beneficial metabolic effects.
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Kristin I. Stanford, Matthew D. Lynes, Hirokazu Takahashi, Lisa A. Baer, Peter J. Arts, Francis J. May, Adam C. Lehnig, Roeland J.W. Middelbeek, Jeffrey J. Richard, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Giovanna Distefano, Vikram K. Shettigar, Michael F. Hirshman, Mark T. Ziolo, Michael A. Kiebish, Yu-Hua Tseng, Paul M. Coen, Laurie J. Goodyear. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metabolism, 2018; 27 (5): 1111 DOI: 10.1016/j.cmet.2018.03.020