Hox genes ( homeobox )

Hox genes ( homeobox )


■ Group of related genes that control the body plan of the embryo along the anterior-posterior (head-tail) axis. ( MORPHOGENESIS GENE)
■ After the embryonic segments have formed, Hox proteins determine the type of segment structures that will form on a given segment.
■ Mutations in human Hox genes result in limb development defects. •
■ HOX-D13 ---- mutated in synpolydactyly
■ HOX-A13 ---- mutated in Hand-Foot-Genital syndrome
■ HOX-A1mutations---- disrupt development of the brainstem, inner ear and cardiovascular system, and to result in mental retardation and autism