Investigational treatment for acne appears promising in laboratory studies - trifarotene
Topical retinoids, which target retinoic acid receptors, are commonly used to treat acne.
New research reveals that trifarotene, a fourth-generation retinoid with potent and selective activity against only one particular retinoic acid receptor, may have an improved efficacy and safety profile compared with less selective retinoids.
J. Aubert, D. Piwnica, B. Bertino, S. Blanchet-Réthoré, I. Carlavan, S. Déret, B. Dreno, B. Gamboa, A. Jomard, A.P. Luzy, P. Mauvais, C. Mounier, J. Pascau, I. Pelisson, T. Portal, M. Rivier, P. Rossio, E. Thoreau, E. Vial, J.J. Voegel. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. British Journal of Dermatology, 2018; DOI: 10.1111/bjd.16719