Least risk of CA breast is seen in -
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- BRCA1
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- BRCA2
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- Li-Fraumeni syndrome
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- Ataxia telangiectasia
0 voters
exp:
- Only about 5 to 10% of breast cancers are caused by inheritance of germline mutations most important of which are BRCA-1 & BRCA-2.
Percent incidence of Sporadic, Familial, and Hereditary Breast Cancer
Sporadic breast cancer - 65-75%
Familial breast cancer - 20-30%
Hereditary breast cancer - 5-10%
BRCA-1 - 45%
BRCA-2 - 35%
p53 (Li-Fraumeni Syndrome) - 1%
STK 11/LKB1 (Peutz-Jeghners syndrome) - <1%
PTEN (Cowden disease) - <1%
MSH2/MLH1 (Muir Torre syndrome) - <1%
ATM (Ataxia-telangiectasia) - <1%
Unknown - 20%