Least risk of CA breast is seen in

Least risk of CA breast is seen in -

    1. BRCA1
    1. BRCA2
    1. Li-Fraumeni syndrome
    1. Ataxia telangiectasia

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exp:

  • Only about 5 to 10% of breast cancers are caused by inheritance of germline mutations most important of which are BRCA-1 & BRCA-2.

Percent incidence of Sporadic, Familial, and Hereditary Breast Cancer

Sporadic breast cancer - 65-75%

Familial breast cancer - 20-30%

Hereditary breast cancer - 5-10%

BRCA-1 - 45%

BRCA-2 - 35%

p53 (Li-Fraumeni Syndrome) - 1%

STK 11/LKB1 (Peutz-Jeghners syndrome) - <1%

PTEN (Cowden disease) - <1%

MSH2/MLH1 (Muir Torre syndrome) - <1%

ATM (Ataxia-telangiectasia) - <1%

Unknown - 20%