MALIGNANT TRITON TUMOR (MTT)
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■ Malignant triton tumor (MTT) is a rare, aggressive tumor
■ Made up of both malignant schwannoma cells and malignant rhabdomyoblasts.
■ It’s classified as a malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation.
■ MPNST (Malignant Peripheral Neural Sheath Tumour) with well developed skeletal muscle component
● Diagnostic criteria of Woodruff :
1)Tumor arises along a peripheral nerve, in a ganglioneuroma, in NF1 patient, or is a metastasis from such a tumor
2) Tumor has characteristics of Schwann cell tumor
3) Rhabdomyoblasts arise from body of tumor
■ Malignant triton tumors are stained ------ for desmin, myoglobin and S-100 protein.