Mallory Denk bodies and Alcoholic hepatitis
( A ) Mallory Denk body is present in another hepatocyte (arrow).
( B ) Alcoholic steatohepatitis with many ballooned hepatocytes (arrowheads). Clusters of inflammatory cells are also present.
■ Inset shows immunostaining for “keratins 8 and 18” (brown), with most hepatocytes, including those with fat vacuoles, showing normal cytoplasmic staining, but in the ballooned cell (arrow) the ubiquinated keratins are collapsed into the Mallory-Denk body, leaving the cytoplasm “empty.”