Paracrine molecular mechanisms that regulate osteoclast formation and function


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Paracrine molecular mechanisms that regulate osteoclast formation and function.
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:white_check_mark: Osteoclasts are derived from the same mononuclear cells that differentiate into macrophages.

:white_check_mark: Osteoblast/stromal cell membrane associated RANKL binds to its receptor RANK located on the cell surface of osteoclast precursors.

:white_check_mark: This interaction in the background of macrophage colony-stimulating factor (M-CSF) causes the precursor cells to produce functional osteoclasts.

:white_check_mark: Stromal cells also secrete osteoprotegerin (OPG), which acts as a “decoy” receptor for RANKL, preventing it from binding the RANK receptor on osteoclast precursors.

:white_check_mark: Consequently, OPG prevents bone resorption by inhibiting osteoclast differentiation.