Potential drugs developed to help curb smoking.
Drug would block breakdown of nicotine, reducing urge to smoke.
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Researchers have created more than a dozen candidate drugs with the potential to curb smokers’ desire for nicotine by slowing how it is broken down in the body.
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The researchers hope the substances can help people reduce their consumption of tobacco, if not quit altogether.
Travis T. Denton, Pramod Srivastava, Zuping Xia, Gang Chen, Christy J. W. Watson, Alec Wynd, Philip Lazarus. Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition. Journal of Medicinal Chemistry, 2018; 61 (16): 7065 DOI: 10.1021/acs.jmedchem.8b00084
