PURE RED CELL APLASIA (PRCA) or ERYTHROBLASTOPENIA:-

USMLE USMLE 1
#1

PURE RED CELL APLASIA (PRCA) or ERYTHROBLASTOPENIA:-
• type of anemia affecting precursors to red blood cells but not to white blood cells
• bone marrow ceases to produce red blood cells.
• Causes include:

  1. Autoimmune disease.
  2. Thymoma
  3. Viral infections---- HIV, herpes, parvovirus B19 (Fifth disease), or hepatitis
  4. T large granular lymphocyte leukemia
  5. Idiopathic.
  6. ABO incompatibility
  7. Drugs, e.g., mycophenolic acid or erythropoietin;NSAIDs
  8. Congenital -----“hereditary pure red cell aplasia” (a/k/a Diamond-Blackfan
    anemia)