PURE RED CELL APLASIA (PRCA) or ERYTHROBLASTOPENIA:-
• type of anemia affecting precursors to red blood cells but not to white blood cells
• bone marrow ceases to produce red blood cells.
• Causes include:
- Autoimmune disease.
- Thymoma
- Viral infections---- HIV, herpes, parvovirus B19 (Fifth disease), or hepatitis
- T large granular lymphocyte leukemia
- Idiopathic.
- ABO incompatibility
- Drugs, e.g., mycophenolic acid or erythropoietin;NSAIDs
- Congenital -----“hereditary pure red cell aplasia” (a/k/a Diamond-Blackfan
anemia)