Regarding this disease of collagen biosynthesis as shown in the image,which of the following statements is true?

Regarding this disease of collagen biosynthesis as shown in the image,which of the following statements is true?

  1. Deficient Hydroxylation secondary to Ascorbate deficiency.
  2. Mutations in Collagen genes.
  3. Mutations in collagen genes and Lysyl hydroxylase gene.
  4. Deficient cross linking secondary to functional copper deficiency

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