Risk factors for Ca Breast are:
c) Family history
d) BRCA 1 mutation
- Nulliparity is a risk factor, not multiparity.
- Schwartz writes -
- Increased exposure to estrogen is associated with an increased risk for developing breast cancer, whereas reducing exposure is thought to be protective.
- Correspondingly, factors that increase the number of menstrual cycles, and thus exposure to estrogen, are associated with an increased risk. These are:
Early menarche - Nulliparity - Late menopause
- There is an association between obesity and increased breast cancer risk. Because the major source of estrogen in postmenopausal women is the conversion of androstenedione to estrone by adipose tissue, obesity is associated with increased exposure to estrogen.
- Family history of even 2nd degree relatives is associated with increased risk, although much less than that with 1Stdegree relatives.
- Administration of estrogens alone is not associated with increased risk of breast cancer
- Concamitant administration of progesterone and estrogen increase the risk of breast cancer. [Harrison 17/e p.563; Sabiston 18/e p864]