Selective 5–HT4 agonist useful in gastroesophageal reflux disease and lacking arrhythmogenic property is :
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- Buspirone
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- Sumatriptan
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- Cisapride
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- Tegaserod
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Both cisapride and tegaserod are selective 5HT4 agonists useful in the treatment of GERD. Cisapride possesses cardiac K+ channel blocking activity and can lead to torsades de pointes. Tegaserod is devoid of this adverse effect. However, tegas-erod has recently been withdrawn due to increased risk of MI and stroke.