Some_autoantibodies:_
1_ #anticentromer_antibodies
occur in limited cutaneous scleroderma,positive in about 60-70% of systemic sclerosis pts.
2 - #anti_ds_DNA_antibodies are highly specific for SLE& core late with disaese activity
3-#antiribonucleprotein_antibodies are positive in 95-100% of pts.of mixed
connective-tissue disaeses.
4-#ANTI_RO_antibodies (anti-SSA) occurs in about 60-70% of pts of Sjögren ’ syndrome.
5-#anti_smith_antibodies have specificity for SLE but with low sensitivity.also occur in8% of mctd.