Thalassemia (Hemoglobin H)


#1

Thalassemia (Hemoglobin H)
:heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign::heavy_minus_sign:
:white_check_mark: (a) α‐Thalassemia: Hemoglobin H disease (three α‐globin gene deletion).

The blood film shows marked hypochromic, microcytic cells with target cells and poikilocytosis.

:white_check_mark: (b) α‐Thalassaemia: haemoglobin H disease.

Supravital staining with brilliant cresyl blue reveals multiple fine, deeply stained deposits (‘golf ball’ cells) caused by precipitation of aggregates of β‐globin chains.