The most unlikely clinical feature of Hepatocellular carcinoma is -

NEET SS
#1

The most unlikely clinical feature of Hepatocellular carcinoma is -

    1. Hepatomegaly
    1. Raised a-fetoprotein levels.
    1. Raised alkaline phosphatase
    1. Jaundice

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ANS:

  • “Jaundice is rare, unless significant deterioration of liver function or obstruction of bile ducts occurs. Serum elevations of alkaline phosphates and alpha fetoprotein are common” — Harrison 16/e (not mentioned in 17th edition)
  • HCC tends to present at late stages because it occurs in patients with underlying cirrhosis and the symptoms and signs may suggest progression of the underlying disease.
  • Symptoms at this advanced stage are
  • vague rt upper quadrant abd. pain
  • nonspecific sym. of advanced malignancy (i.e. anorexia, wt. loss, lethargy)
  • Hepatomegaly or a mass is palpable in many patients.
  • Serum elevation of alkaline phosphates and a feto-protein are common.
  • Most common symptom- abdominal pain.
  • Most common physical sign- hepatomegaly