The Sputum Cytology shows Characteristic CHARCOT-LEYDEN CRYSTALS. Creola Bodies, Curschmann Spirals(Formed by Mucus) and Charcot-Leyden Crystals are seen in Sputum Cytology of Bronchial Asthma. These Charcot-Leyden Crystals are formed by Eosinophils.
The diagnosis based on the clinical history and the cytological examination of the sputum is a case of Bronchial Asthma.
Sputum analysis in asthma reveals one or more of the following:
Curschmann spirals: whorled mucous plug in sputum that is formed by shed bronchial epithelium.
Charcot-Leyden crystals (as seen in the image)
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histopathologic finding in patients with eosinophilic inflammation and proliferation
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composed of galectin-10 protein.
Creola bodies: aggregate of desquamated epithelial cells.
Other diagnostics of asthma
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An obstructive pattern of airflow limitation on PFT
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↓ FEV1 & ↓ FEV1/FVC ratio on spirometry
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Bronchial reversibility tests: Obstruction is reversible with a bronchodilator (e.g., increase in FEV1 > 12%)
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FEV1 reduction > 20% with methacholine challenge test
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CBC: possible eosinophilia
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Single-breath diffusion capacity: normal or ↑ DLCO.