There is little improvement after salbutamol. What is the most likely diagnosis?

Pulmonary function tests reveal a reduced FEV1/FVC ratio, reduced gas transfer and increased total lung capacity. There is little improvement after salbutamol. What is the most likely diagnosis?
A. Pneumonia
B. COPD
C. Pulmonary embolism
D.Asthma
E. Interstitial lung disease