These drugs work by which of the following mechanisms?

Drugs such as cholestyramine and colestipol have been shown to decrease circulating serum LDL cholesterol and to slightly elevate triglycerides. These drugs work by which of the following mechanisms?

  • (A) Binding and excretion of bile-soluble lipids
  • (B) Decreased peripheral lipolysis
  • © Increased lipoprotein lipase activity
  • (D) Inhibition of cholesterol absorption at the small intestine brush border
  • (E) Inhibition of the rate-limiting enzyme of cholesterol formation
  • (F) Retention of bile acid resins in hepatocytes

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