These drugs work by which of the following mechanisms?


#1

Drugs such as cholestyramine and colestipol have been shown to decrease circulating serum LDL cholesterol and to slightly elevate triglycerides. These drugs work by which of the following mechanisms?

  • (A) Binding and excretion of bile-soluble lipids
  • (B) Decreased peripheral lipolysis
  • © Increased lipoprotein lipase activity
  • (D) Inhibition of cholesterol absorption at the small intestine brush border
  • (E) Inhibition of the rate-limiting enzyme of cholesterol formation
  • (F) Retention of bile acid resins in hepatocytes

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