Transient Hypogammaglobulinemia of Infancy;
Primary Immuno-deficiency
Humoral Immunodeficiency: B Cell defect
Seen in both sexes
Results due to abnormal delay in the initiation of IgG synthesis in some infants
disease manifests after 6 months when passive protection with maternal antibodies ceases
spontaneous recovery occurs between 18-30 months of age.
Presentation: Recurrent otitis media and respiratory infections.
treatment with gammaglobulins not recommended as Immunodeficiency can be prolonged as a result of negative feedback effect on IgG synthesis