Triads of some important diseases

►TRIAD OF ALPORT’S SYNDROME –
• SENSORINEURAL DEAFNESS,
• PROGRESSIVE RENAL FAILURE,
• OCULAR ANOMALIES

►TRIAD OF BEHCET’S SYNDROME –
• RECURRENT ORAL ULCERS,
• GENITAL ULCERS,
• IRIDOCYCLITIS.

►BECK’S TRIAD –
• MUFFLED HEART SOUND,
• DISTENDED NECK VEINS,
• HYPOTENSION.

►CHARCOT’S TRIAD –
• PAIN+FEVER+JAUNDICE

►GRADENIGO’S TRIAD -
• SIXTH CRANIAL N. PALSY,
• PERSISTANT EAR DISCHARGE,
• DEEP SEATED RETRO-ORBITAL PAIN

►Triad Of Hypernephroma –
• pain+
• hematuria+
• renal Mass.

►Triad of Wilm’s tumor:
• Fever +
• Mass +
• Hematuria

►Hutchinson’s Triad —
• Hutchison’s Teeth,
• Interstitial Keratitis,
• Nerve Deafness.

►Triad Of Kwashiorkar-
• Growth Retardation,
• Mental Changes,
• Edema.

►Saint’s Triad —
• Gall Stones,
• Diverticulosis,
• Hiatus Hernia.

►Trotter’s Triad –
• Conductive Deafness,
• Immobility Of Homolateral Soft Palate,
• Trigeminal Neuralgia.
Mnemonic: NPC- neuralgia, palatal paralysis, conductive
deafness

►VIRCHOW’S TRIAD –
• STASIS+
•HYPERCOAGULABILTY+
• VESSEL INJURY.

►SAMTER’S TRIAD –
• ASPIRIN SENSITIVITY,
• BRONCHIAL ASTHMA,
• NASAL POLYP.

►Grancher’s triad–
• lessened vesicular quality of breathing,
• skodaic resonance, and
• increased vocal fremitus; seen in early pulmonary
tuberculosis.

►Osler’s triad–
• telangiectasis,
• capillary fragility, and
• hereditary hemorrhagic diathesis seen in hereditary
hemorrhagic telangiectasia.

►BARTTER’S SYNDROME -
• METABOLIC ALKALOSIS,
• HYPOKALEMIA,
• NORMAL OR DECREASED BP.

►Weil’s Disease–
• Hepatorenal Damage,
• Bleeding Diathesis,
• Pyrexia.

►Meniere’s Disease –
• Vertigo,
• Tinnitus,
• Sensorineural Hearing Loss.

►Melkersson Rosenthal Syndrome–
•recurrent Facial Palsy,
•Plication Of Tongue,
•Facial Edema.

►Parkinsonism–
•Rigidity,
•Tremor
•Hypokinasia

►Cushing’s traid –
•Bradycardia,
•hypertension &
•irregular respirations in increased intracranial
pressure.

►Kartagener’s Syndrome–
•bronchiectasis,
•Recurrent sinusitis, and
•Situs inversus.

►Hemobilia(Triad of Sandblom)–
•Malena,
•Obstructive jaundice,
•Biliary colic.

►Murphy’s triad(in order)-
•Pain,
•Vomitting,
•Fever.

►WHIPPLE’S TRIAD Of INSULINOMA–
•HYPOGLYCAEMIA DURING ATTACKS,
•S.GLUCOSE <40 mg%,
•PROMPT RELIEF ON GLUCOSE ADMINISTRATION.

►Triad of HUS
•hemolytic anemia +
•acute renal failure +
•thrombocytopenia

►Triad of alkaptonuria
•Homogentistic aciduria
• Black pigmentation of cartilage and collagenous tissue
•Ochronotic arthritis

►Classic triad of Chronic mercury poisoning
•Excessive salivation and gingivitis
•Tremors
•Neuropsychiatric changes

►Adams triad or Hakim’s triad for Normal Pressure
•Hydrocephalus
•urinary incontinence,
•gait disturbance, and dementia

►Bezold’s triad: Three symptomatic indications of
otosclerosis:
•diminished aural perception of low frequency tones,
• retarded bone conduction,
• negative Rinne test

►Hand-Schüller-Christian disease triad of
•exophthalmos,
•lytic bone lesions (often in the skull), and
•diabetes insipidus

►UNHAPPY TRIAD
An unhappy triad (or terrible triad, “horrible triangle”,
O’Donoghue’s triad or a “blown knee”) is an injury to the
anterior cruciate ligament, medial collateral ligament, and
the meniscus. The triad refers to a complete or partial tear
of the anterior cruciate ligament, medial collateral
ligament, and the meniscus.

►Dieulafoy’s triad:
•hyperesthesia of the skin,
•exquisite tenderness and
•guarding over McBurney’s point, considered a classic
sign of acute appendicitis

►Vogt Triad of tuberus sclerosis: Mental Retardation
Adenoma Sebaceum Seizures

►Miller fisher syndrome:Variant of GBS. It usually affects
the eye muscles first and presents with the triad of
•ophthalmoplegia, •ataxia, and •areflexia.

►Classic triad of Wernicke encephalopathy are
•encephalopathy, •ataxic gait, •ophthalmoplegia!

►Carney Triad :::
•gastric epithelioid leiomyosarcoma (these are now
known to actually be malignant gastrointestinal stromal
tumors),
• pulmonary chondroma, and
•extra-adrenal paraganglioma. .

►Atta’s triad of bilharzial dysentery:-.
•Bleeding per rectum.
•Polyposis.
•Clubbing of fingers

►Loeys-Dietz syndrome is phenotypically distinct from
Marfan syndrome… Loeys-Dietz syndrome is an
aggressive, autosomal dominant condition that is
distinguished by the triad of
•arterial tortuosity and aneurysms,
•hypertelorism (widely spaced eyes), and
•bifid uvula or cleft palate.

►Classic triad in Gardner’s Syndrome:
colonic polyps
bone tumors
soft tissue tumors

►Borchardt’s triad
epigastric pain, nausea, inability to pass nasogastric
tube… seen in gastric volvulus

►Triad of shaken baby syndrome:
•subdural
•hematoma , retinal hemorrhage , and
•cerebral oedema.

►Beck’s cognitive triad is a triad of types of negative
thought present in depression:
•The self (i.e., self is worthless)
•The world/environment (i.e., world is unfair), and
•The future (i.e., future is hopeless).

►Felty triad
•Neutropenia
•RA
•SPlenomegaly

►Behcet’s syndrome
The clinical triad of uveitis with recurrent oral and genital
ulcers–

►Macdonald triad
The Macdonald triad is a set of three behavioral
characteristicswhich are associated with sociopathic
behavior. These behavioral characteristicsare found in the
childhood histories of individuals with sociopathic
behavior:
•Enuresis (bedwetting)
•Firesetting
•Torturing small animals

►MARSHALL’S TRIAD, when considering the pathology of
trauma of bomb explosions. The triad includes
•punctate-bruises,
•abrasions and
•small punctate lacerations all of which are typically found
in an explosive bomb blast. Although many similarities
exist between injury patterns seen in lightning and
concussive injuries, Marshall’s Triad findings are not
typically found in lightning strike injuries.

►Van der Hoeve syndrome presents with the triad of
•osteogenesis imperfecta,
•otosclerosis and
•blue sclera.

►Classical triad of Aortic stenosis(valvular dx)-
• dyspnea,
• angina and
• syncope.

►the classic Rigler’s triad of gallstone ileus:
• pneumobilia;
• small bowel obstruction; and
• an ectopic gallstone

►VIRchow’s triad for venous thrombosis:
Vascular trauma
Increased coagulability
Reduced blood flow

►Mackler’s triad which includes
• chest pain,
• vomiting and
• subcutaneous emphysema,
while classical, is only present in 14% of
people with Boerhaave syndrome .

►Ohashi triad:
• Neoplasms with mucin hyper— production,
• dilatation of the duct of Wirsung, and
• protruding papilla (the Ohashi triad)

►Abnormalities in Congenital Rubella: Triad of Gregg :
• cataract,
• deafness, and
• heart defect

►Currarino syndrome (or triad) is defined as a partial
sacral agenesis associated with a presacral mass and
ano-rectal malformation.

►Triad of alkaptonuria
• Homogentistic aciduria
• Black pigmentation of cartilage and collagenous tissue
• Ochronotic arthritis

►Dieulafoy’s triad::
• Hypersensitivity of the skin,
• tenderness and
• muscular contraction at McBurney’s point in acute
appendicitis.

►Triad of somatostatinoma
• Diabetes mellitus
• Steatorrhoea
• Cholecystolithiasis.