True about local anaesthetic agents –

True about local anaesthetic agents –

1.Duration depends on protein binding
2.Protency depends upon lipid solubility
3.La with low PK a is more active
4.Higher dose produced more back
5.All othe above

Explanation

Duration of LAs depends on lipid solubility, protein binding, metabolism, Dose (higher dose produces longer block), vasoconstrictor, and sodium bicarbonate.
Potency correlates with lipid solubility.
LA with pKa closer to physiological pH has more rapid onset of action.
LAs block the generation and propagation of impulses in electrically excitable tissue (e.g. nerves). Transmission of electrical impulses along the cell membrane is the basis of signal transduction, therefore LAs interfer with signal transduction.