True about papillary carcinoma thyroid is-
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- Comprises 10-15% of all thyroid cancers
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- Cells have intranuclear vacuolation.
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- Amyloid deposition seen
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- Encapsulated
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ANS
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Papillary thyroid cancers are the most common type of thyroid cancer, accounting for nearly 85% of primary thyroid malignancies.
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“Papillary carcinomas are solitary or multifocal lesions. Some tumors may be well circumscribed and even encapsulated; others may infiltrate the adjacent parenchyma with illdefined margins.” - Robbins
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Histological characteristics of PTC:
- Papillary projections
- PTC contains branching papillae of cuboidal epithelial cells.
ii. Orphan Annie eye nuclei:
The nuclei of papillary carcinoma cells contain finely dispersed chromatin, which imparts an optically clear or empty appearance, giving rise to term ground glass or Orphan Annie eye nuclei.
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In addition, invaginations of the cytoplasm may in cross-sections give the appearance of intranuclear inclusions (pseudo-inclusion) or intranuclear grooves.
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the diagnosis of papillary carcinoma is based on these nuclear characteristics even in the absence of papillary structures.
iii. **Psammoma bodies**
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these are concentrically calcified structures.