TYPES OF COLLAGEN, DISTRIBUTION AND DISORDERS
- Fibrillar collagens
Type: I
Distribution: Bone, cornea, myofibrils
Disorder: Osteogenesis imperfecta, Ehler Danlos, arthrochalasias type I
Type: II
Distribution: Cartilage, intervertebral disc, vitreous
Disorder: Achondrogenesis type II, spondyloepiphysea dysplasia syndrome
Type: III
Distribution: Hollow organs, soft tissues, granulation tissue
Disorder: Vascular Ehlers Danlos
Type: V
Distribution: Soft tissues, blood vessels
Disorder: Classical Ehler Danlos
Type: IX
Distribution: Cartilage, vitreous
Disorder: Stickler syndrome
- Basement membrane collagens
Type: IV
Distribution: Basement membranes, eye lens
Disorder: Alport syndrome
- Other collagens
Type: VI
Distribution: Ubiquitous in microfibrils
Disorder: Bethlem myopathy
Type: VII
Distribution: Anchoring fibrils at dermal epidermal junctions
Disorder: Dystrophic epidermolysis bullosa
Type: IX
Distribution: Cartilage, intervertebral discs
Disorder: Multiple epiphyseal dysplasias
Type: XVII
Distribution: Transmembrane collagen in epidermal cells
Disorder: Benign atrophic generalized epidermolysis bullosa
Type: XV and XVIII
Distribution: Endostatin forming collagens, endothelial cells
Disorder: Knobloch syndrome