Undifferentiated acute leukemias

AMBIGUOUS LEUKEMIA:

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3 TYPES:

  1. UNDIFFERENTIATED ACUTE LEUKEMIAS:
    Lack morphologic or immunologic differentiating features;
    Blasts cell express HLA-DR,CD34,CD38,TdT( terminal deoxynucleotidase) and CD7.
  2. BILINEAL ACUTE LEUKEMIA:
    Two populations of blasts expressing distinct lineage markers of myeloid or lymphoid origin or B- and T-cell lineage
  3. BIPHENOTYPIC ACUTE LEUKEMIA:
    Same Blast cell coexpress myeloid and lymphoid antigen both …usually seen in BLAST CRISES OF CHRONIC MYELOID LEUKEMIA