What are the tests that can diagnose the patient of the rona???
The question spread this period everywhere
Very important for doctors
**** and the answer is that the only current and certified analysis of the diagnosis of corona virus cases is only the PCR
RT-PCR is considered the gold standard of diagnosis for COVID-19
Considering that the sensitivity of analysis ranges from (93 %) if the sample taken (Bronchoalveolar lavage fluid) to (32 %) if the sample (Pharyngeal swabs)
Note: Analysis allergies are about (63 %) if the sample (Nasal swabs)… blood samples found that the allergies are only (1 %) and therefore the analysis is not done from blood samples
**** ok for the job of the serology or the fast cards of the virus based on the IGG, IGM… Currently it’s still in the stage of studies for the behavior of the virus and the way to treat the immune system with it there is no information Confirmed about the benefit of using this analysis… It is also practically sensitive and specialty (Sensitivity and specificity) has a lot of words and a lot of socket that the cDC recently (Tuesday 28/5) said that the test Prove wrong whether positive wrong or negative wrong in about half cases and therefore cannot be used as a replacement for PCR right now
Currently they aren’t very reliable, often producing false-negative and false-positive results. The CDC says they aren’t accurate enough yet to make important policy decisions.
The rapid antibody tests used to find out whether someone has already been infected with the coronavirus are only right half the time, new guidance from the U.S. Centers of Disease Control and Prevention (CDC) said.
**** ok the story of the chest ray and diagnosis of cases… whether your daughter is talking about the Chest x-ray or the chest ct scan there is no specific recommendation for the possibility of using them as an alternative to diagnosis… In a great conflict in use, for example China is highly likely to use while the CDC and ACR recommends not to use routine to scan to diagnose the corona infection. But it’s duty to leave it to fellow radiologists to make it more clear
While patients with COVID-19 can show an abnormality on either a chest x-ray or CT scan, many other lung problems can look very similar. Additionally, the absence of an abnormality on either a chest x-ray or CT scan does not necessarily exclude COVID-19. For this reason, most experts and medical societies advise against the use of an imaging test to diagnose or rule out COVID-19.
The American College of Radiology (or ACR), which represents nearly 40,000 radiologists in the United States, has issued guidance that CTs and x-rays should not be used as a first-line tool to diagnose or screen for COVID-19.
The Centers for Disease Control (CDC) does not currently recommend CXR or CT to diagnose COVID-19. Viral testing remains the only specific method of diagnosis. Confirmation with the viral test is required, even if radiologic findings are suggestive of COVID-19 on CXR or CT.
**** Nigerian for the topic of medical analysis and the spread of use to diagnose cases… Of course there is no controversial that all the routine tests used in relation to the corona virus are non-specific analysis meaning that the positive result does not mean The virus infected and the negative result also does not deny injury
So the term using tests in diagnosis of corona is very wrong
It is true that from research on the patients that are sure to have actually found changes in the results in some tests, so it is possible to do these tests of some patients suspected of being injured and positive results confirm the need then there are symptoms and Rays and PCR analysis
The results found in the following corona disease include:
** (lymphopenia) in blood picture
With the beginning of the injury and during the period of the incubation period, he found that blood leukocyte and lymphocyte counts are normal or slightly reduced) but after this period, the symptoms of the disease begin to appear and here it is in (Significant lymphopenia and in research that explains this That lymphocite cells have the ACE2 receptor that the virus attacks and therefore lead to their lysis
Research also found that the degree of lymphopenia is as important as prognostic factor
The degree of lymphopenia is higher in severe COVID-19 patients than in mild cases, and is associated with the disease severity.
And in a study in China I found this
On admission, the vast majority of patients presented with lymphocytopenia (83.2%), whereas 36.2% had thrombocytopenia, and 33.7% showed leukopenia.
** ال (inflammatory markers)
After the nursery period of the virus, it will happen (systemic increase of inflammatory mediators and cytokines) especially the IL-6, IL-2, IL-7, and this we can measure it with the high signs of the process Ziz!
ال (erythrocyte sedimentation rate)
And the C-reactive protein (CRP)
And research is likely to use CRP early in sick condition and recommended that it be used to follow up
At the early stage of COVID-19, CRP levels were positively correlated with lung lesions. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring.
** ال (hyperferritinemia)
Of course the Serum ferritin is known as a protein used to store iron in the liver… but in addition to that, the fritines are one of the well known inflammatory marker or the positive acute-phase proteins so it makes sense that it increases In inflammatory infections including pneumonia in corona disease
In an Italian study, they found that its increase is proportionate to the disease and high death rates so it is a very good analysis to follow up
At low concentrations, they are safe for the body and help to protect it against viruses and bacteria. At high levels, the so called “cytokine storm” develops, which can be lethal for half of the patients, especially for the elderly,’ explains Yehuda Shoenfeld. 'Thus, hyperferritinemia has been associated with increased illness severity and adverse outcomes, including COVID-19.
** The (D-dimer)
This is a type of fibrin degradation product… Protein pieces produced after a clot (blood clot) and then cracking it with fibrinolysis process and its main use laboratory diagnosis cases diagnosis (diagnose thrombosis) like the (deep venous thrombosis) and also used to diagnose cases of disseminated intravascular coagulation
Research found that deaths caused by virus infections as a result of thrombosis especially (pulmonary embolism)
Massive pulmonary embolism was the cause of death in one third of the cases, with an additional one fourth with recent deep venous thrombosis but without pulmonary embolism.
So it makes sense that in these cases the D-dimer rises
Patients with COVID-19 infection and pulmonary embolus had higher D-dimer levels than those without pulmonary embolus
And in a Chinese study they found that the rise of d-dimer when entering the hospital will be proof of high risk of mortality and therefore use it to follow up the situation is important and lead to improve the handling of cases
D-dimer on admission greater than 2.0µg/mL (fourfold increase) could effectively predict in-hospital mortality in patients with Covid-19, which indicated D-dimer could be an early and helpful marker to improve management of Covid-19 patients.
** ال (liver enzymes)
Studies have found that some patients (in a study that says more than one third of patients) found a high level of liver enzymes and not known is the liver damage or dysfunction) is the result of the virus itself or is it coming with the use of medicines (potentially hepatotoxic drugs at the hospital
So we can say that liver enzymes can consider it a preliminary test to appreciate the use of the right medicine for the condition and not increase their impact on the liver in cases that already have a problem from the first in the liver like fatty liver
** Lactate dehydrogenase
LDH enzyme is known as the old-used enzymes to evaluate heart clot cases
But also this enzyme is found in many tissue like lung, pancreas, liver, red blood balls, brain, muscles and height of enzyme in general we can say it is the result of
elevated level of lactate dehydrogenase usually indicates tissue damage
And for the patients of corona, he found that the rise of the LDH has an important indicator for the tissue breakdown that may be caused by their lung problem and therefore the enzyme and its presence is high is important and vital to identify patients in need attention More medical or focused care
. In particular, relatively high levels of LDH alone seem to play a crucial role in distinguishing the vast majority of cases that require immediate medical attention. This finding is consistent with current medical knowledge that high LDH levels are associated with tissue breakdown occurring in various diseases, including pulmonary disorders such as pneumonia.
This was most of the tests spread between the labs in cases of corona… I tried to collect information as short as possible to be useful to fellow specialists in dealing with these cases
" O Allah, distract us from the epidemic, may Allah have mercy on us with your mercy, may Allah raise us scourge, Lord of the worlds and prayer and peace be upon the messenger of Allah peace be upon